3D Tissue Systems Symposium

On Tuesday September 27th, the 3D Tissue Systems Symposium took place at Odéon, hosted by Université Paris Cité. This event brought together a hundred participants, who had the opportunity to hear from a panel of expert speakers gathered to present their research using 3D tissue systems, which are revolutionizing in vitro studies.

This day was also an opportunity to hold the IHM General Assembly, during which Clémence Granier announced the launch of the Cytometry DIU.

We were honored to welcome Christine Guillard, Director of the Research and Innovation Division, and Matthieu Resche-Rigon, Dean of the Faculty of Health, who officially opened the event.

Talk by Pr. Jennifer Rohn

Bacteria meets host: unravelling the dynamics of urinary tract infection using complex human microtissue models.

Professor Jennifer Rohn from University College London gave a captivating keynote talk on: “Bacteria meets host: unravelling the dynamics of urinary tract infection using complex human microtissue models”

She highlighted the high prevalence of recurrent urinary tract infections (UTIs), driven by the limitations of antibiotics in completely eradicating bacteria, particularly E. coli. These bacteria invade urothelial cells, forming intracellular reservoirs that evade detection in urine tests and resist conventional treatments. She presented the innovative 3D UHU (Urine-tolerent Human Urothelial model) she developed, which accurately replicates human urothelium with its three cell types and precise biomarker distribution. This innovative model enables a wide range of applications, from testing novel drugs to modeling bladder cancer and studying catheter-associated infections. Among the exciting advancements discussed, promising trials with a new antibiotic capable of penetrating infected cells—demonstrated remarkable efficacy. This model offers invaluable insights into bacterial invasion mechanisms, treatment failures, and persistent challenges like biofilm formation and intracellular bacterial pods.

The other presentations kept us captivated through the entire day:

Emmanuel Donnadieu, Institut Cochin: Predicting safety and efficacy of engineered T cells using an ex vivo human model.
Nicolas Gaudenzio, Infinity: In situ profiling of immune response to injectable drugs using biostabilized natural human skin modules.
Sylvain Lefort, Centre de recherché en cancérologie de Lyon : A human bone marrow model to investigate the dynamics and interactions of macrophages
Diana Passaro, Institut Cochin: Vascular intergration in 3D models to study the human bone marrow microenvironment in leukemia.
Valéria Bisio, IRSL, INSERM U116, Hopital Saint Louis: The mesenchymal stromae cells: a hub for NK immune dysregulation in MDS context.
Guillaume Sarrabayrouse, UTCBS, Université Paris Cité: Intestinal mucosal culture : a useful tool for assessing the early dialogue between host and microbiota.
Samy Gobaa, Institut Pasteur: Developing 2D model systems.