Presentation

The “Institut Hors-Murs” of Immunology and Immunopathology aims to facilitate the production of new knowledge and enhance its dissemination and visibility both nationally and internationally. It reaches a broad audience, ranging from the scientific and medical community to patients, their associations, and the general public, either directly or through educational institutions and associations, as well as industry professionals and policymakers. It is directed by Dr. Anne Hosmalin and Prof. Luc Mouthon.

Image provided by:

Alberto Iannuzzo, Institut Cochin, Université Paris Cité

View of human cells known as “fibroblasts,” derived from the skin of mutated patients to highlight the role of CDC42, an intracellular protein involved in cell organization. The protein appears in pink, actin filaments in green, and the nucleus in blue.

Axis 1: Fundamental Immunology and Immunopathology.

Philippe Bousso, Frédéric Rieux-Laucat


Axis 2: Systemic or organ-specific dysimmune pathologies, patient cohorts, translational research.

Luc Mouthon, Christine Bodemer

  • Cohorts of patients with dysimmune diseases or transplant recipients with a biobank.
  • Standardization of samples.

Axis 3: Innovative experimental models, including tissue approaches, organoids, stem cells, etc.

Marjolaine Gosset, Antoine Toubert

  • Ex-vivo approaches
  • Animal experimental models: inventory of existing and future animal experimental models.

Axis 4: Omic approaches to structural biology.

Darragh Duffy, Nicolas Leulliot

  • Multi-omic approaches: metabolomics, proteomics, transcriptomics, genomics.
  • Platforms of Université Paris Cité.
  • Validation of omic approaches through structural biology methods.
  • Artificial intelligence, in collaboration with the Prairie group.
  • Identification of diagnostic and prognostic markers/algorithms.

Axis 5: Innovative/targeted therapies based on immune mechanisms, innovative and sustainable exploration tools.

Jonathan Pol, Clémence Granier
Particularly in the following pathologies:

  • Malignant tumors.
  •  Autoimmune/dysimmune diseases.
  • Infectious diseases.
  • Transplantation.

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